Successful HLA haploidentical myeloablative stem cell transplantation for aggressive hepatosplenic alpha/beta (αβ) T-cell lymphoma
نویسندگان
چکیده
Hepatosplenic T cell lymphoma (HSTCL) is a type of hematologic neoplasia with a poor prognosis and a high frequency of refractoriness to conventional chemotherapy. The results obtained by high dose chemotherapy followed by autologous stem cells transplantation seem to be a more effective option but still unsatisfactory. Also the role of allogeneic stem cell transplantation is still unclear, although the few cases reported on the literature would seem to show good results in overall survival rates. In this paper, we reported the patient׳s medical history affected by a αβ variant of hepatosplenic T cell successfully rescued with a haploidentical transplant.
منابع مشابه
Successful treatment of hepatosplenic T-cell lymphoma with ESHAP followed by autologous stem cell transplant.
Hepatosplenic T-cell lymphoma (HSTCL) was first described as a distinct clinicopathologic entity in 1990.1 HSTCL is a rare type of non-Hodgkin lymphoma that was originally recognized by its characteristic clinical presentation, distinct histologic pattern, and expression of the γδ T-cell receptor (TCR).1 Recent scientific advances have allowed for better understanding of the histologic, immunop...
متن کاملRole of Stem Cell Transplantation in the Treatment of Burkitt Lymphoma; A Systematic Review
Background: Burkitt lymphoma is a common subtype of non-Hodgkin lymphoma in children. It has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. Systemic chemotherapy is the mainstay of the treatment for this malignancy in children. In this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (HSC...
متن کاملOutcomes of allogeneic stem cell transplantation in hepatosplenic T-cell lymphoma
Hepatosplenic T-cell lymphoma (HSTCL) is a rare but aggressive type of non-Hodgkin lymphoma that primarily involves the sinusoids of the liver, red pulp of the spleen and the sinuses of the bone marrow. The specific rearrangement of the expressed T-cell receptor chain genes (TCR-αβ vs γδ) determines the subtype of the disease (HSαβTCL vs HSγδTCL). HSαβTCL is the rarer subtype with fewer than 30...
متن کاملRole of αβ T Cell Depletion in Prevention of Graft versus Host Disease
Graft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD. The αβ T cells are considered the primary culprit for causing GVHD therefore depletion of this T cell subset emerged as a promising cellular manipulation strategy to overcome the human leukocyte...
متن کاملSuccessful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling.
Primary plasma cell leukaemia (PCL) is a rare, aggressive neoplasm of plasma cell dyscrasia. Conventional chemotherapy is usually ineffective, with an overall survival of only 8 months. Here, we describe a 42-year-old man with primary PCL, who was successfully treated with haploidentical (2-HLA loci mismatched) haematopoietic stem-cell transplantation (HSCT). To overcome the human leukocyte ant...
متن کامل